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Collins, FS and VA McKusick, Implications of the Human Genome Project for Medical Science, JAMA, 285, 540 544 (2001) Dobbs, DB, The Law of Torts St Paul, MN: West Group, pp 975 976 (2000) Eisenberg, RS, The Shifting Functional Balance of Patents and Drug Regulation, Hlth Affairs, 20(5), 119 135 (2001) Epps, PG and MA Rothstein, Pharmacogenomics: Ensuring Equity Regarding Drugs Based on Genetic Difference, In: J Licinio and M-L Wong (eds), Pharmacogenomics: The Search for Individualized Therapies Weinheim, Germany: WileyVCH (2002) Evans, WE and MV Relling, Pharmacogenomics: Translating Functional Genomics Into Rational Therapeutics, Science, 286, 5439 5491 (1999) Food and Drug Administration (FDA) (1999) Final Guidance on Direct-toConsumer Advertising Federal Register 64:43,197 198, available at wwwfdagov/cder/guidance/1804fnlhtm (accessed May 26, 2002).

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Food and Drug Administration (FDA) (2002) Report to Congress on PostMarketing Surveillance of Drugs, March 13, 2002, available at wwwfdagov/cber/fdama/pstmrktfdama130htm (accessed May 30, 2002) Foster, MW and RR Sharp, Race, Ethnicity, and Genomics: Social Classi cations as Proxies of Biological Heterogeneity, Genome Res, 12, 844 850 (2002) Gilhooley, M, When Drugs Are Safer for Some But Not Others: The FDA Experience and Alternatives for Products Liability, Houston L Rev, 36, 927 949 (1999) Holtzman, NA, Putting the Search for Genes in Perspective, Intl J Hlth Serv, 31, 445 458 (2001) International Human Genome Sequencing Consortium, Initial Sequencing and Analysis of the Human Genome, Nature, 409, 860 921, (2001) Knoppers, BM, Of Populations, Genetics and Banks, Genet Law Monit, Jan Feb, 3 6 (2001).

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The Lancet, Europe on the Brink of Direct-to-Consumer Drug Advertising, Lancet, 359, 1709 (2002) Lazarou, J, et al, Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-Analysis of Prospective Studies, JAMA, 279, 1200 1205 (1998) Lee, SS-J, et al, The Meanings of Race in the New Genomics: Implications for Health Disparities Research, Yale J Hlth Policy L Ethics, 1, 33 75 (2001) McCormick, R, Pharmaceutical Manufacturer s Duty to Warn of Adverse Drug Interactions, Defense Counsel J, 66, 59 68 (1999) Moldrup, C, When Pharmacogenomics Goes Public, New Genet Soc, 21, 29 37 (2002) National Institute of Environmental Health Sciences (NIEHS) (2001) Environmental Genome Project Overview, wwwniehsgov/envgenom/concepthtm (accessed May 27, 2002) National Institutes of Health, Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research, 59 Fed Reg 14,508, (1994) Noah, L.

, Advertising Prescription Drugs to Consumers: Assessing the Regulatory and Liability Issues, Ga L Rev, 32, 141 180 (1997)..

2) If, moreover, S and S are nitary, then: the sequence of relations N 0 admits as a limit R with R = N 0 E N (R). R is the greatest xed point of the function E, i.e. E(R ) = R and E(A) = A A R . 3) If, moreover, S and S are nite then: R = E K (R) where k = max(|S|, |S |).

Proof These assertions are trivial consequences of the state change equation For instance, the proof of the rst point is as follows: v t m = v t m + v t C = v t m DEFINITION 314 (Linear invariants) Let (R, m0 ) be a marked net, a linear invariant denotes the equation: m A(R, m0 ), v t m = v t m0 where v is a P - ow In the case of a P -semi ow, we say that it is a positive invariant The positive invariants have numerous applications For instance, every place belonging to the support of a P - ow v is bounded whatever the initial marking, since m(p) v(p) 1 v t m0 Similarly, from an invariant m(p) + m(q) + = 1, we deduce that p and q cannot be simultaneously marked.

More generally, invariants are the basis of numerous necessary and/or suf cient conditions of behavioral properties In order to develop this point, we introduce two structural properties of a Petri net DEFINITION 315 (Conservative nets, consistent nets) Let R be a Petri net: R is conservative if there is a P -semi ow v such that v = P R is consistent if there is a T -semi ow v such that v = T We illustrate this section with the net presented in Figure 33 Two processes (A and B) repeatedly execute one of the two local procedures (H or V ), then synchronize themselves to exchange their results The synchronization is only possible if both processes have chosen the same procedure Observe that the net is bounded (exactly two tokens in every reachable marking) and not live, since different choices lead to a deadlock.

Markets, Content, and Management Model Chosen, Is It Time to Translate At this point you have picked your target markets, developed your core content catalog, and perhaps determined that you will you manage international sites from your headquarters country. However, except for closely related languages and markets such as Spanish-speaking countries in Latin America signi cant technology preparation precedes translation, and some heavy-duty logistical adaptation follows it (see Figure 6.2). Without this prep work, translation will result in odd-looking passages for example, French or Czech without their accents and diacritical marks.

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